A nadA Mutation Confers Nicotinic Acid Auxotrophy in Pro-carcinogenic Intestinal Escherichia coli NC101
Inflammatory bowel diseases (IBDs) and inflammation-associated colorectal cancer (CRC) are linked to blooms of adherent-invasive Escherichia coli (AIEC) in the intestinal microbiota.AIEC are functionally defined by their ability to adhere/invade epithelial cells and survive/replicate within macrophages.Changes in micronutrient availability can alte